Research that works for developing countries and AustraliaAntigenic competition and vaccine failure in small ruminant vaccines in India: A preliminary investigationProject ID: AS1/1994/113: Antigenic competition and vaccine failure in small ruminant vaccines in India: A preliminary investigationCollaborating Countries: IndiaCommissioned Organisation: University of Sydney, AustraliaProject Leader Dr John Egerton Phone: 02 9351 1606 Fax: 02 9351 1618 Email: johne@camden.usyd.edu.au Collaborating Institutions:
Project Budget: $74,916Project Duration: 01/07/1995 - 31/12/1996Project Extension: 31/12/1996 - 30/06/1998ACIAR Research Program Manager Dr John Copland Project Background and Objectives Sustainable livestock production requires the development and implementation of non-toxic natural methods for disease control and modification of production including vaccination and breeding of genetically superior animals. Multi-component vaccines that enable several vaccines to be incorporated into a single injection would help maximise production. However, some of the most advanced livestock vaccines in Australia have been found to be limited by competition for immune response between components (antigens) in the vaccines. As the number of components increases in a single vaccine, functional immunity to each component is reduced. This small project aims to investigate the occurrence of antigenic competition in vaccinated small ruminants in India and to identify differences and similarities in responses of sheep and goats. It will also define the steps in the immune response that cause the phenomenon of antigenic competition and will look for ways to overcome it. Project Outcomes Outcomes for this project are currently being prepared |
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